Engineering a DNA damage response without DNA damage
نویسندگان
چکیده
منابع مشابه
DNA Damage Response Pathways
ownload B4 is unusual among receptor tyrosine kinases because some isoforms can be efficiently cleaved at the a membrane to release a soluble intracellular domain. The cleavage product has high kinase activity mes to the nucleus. A screen for proteins that associate with the ErbB4 intracellular domain identified ate interactors including ITCH, WWP2, Nucleolin, and Krab-associated protein 1 (Kap...
متن کاملDNA damage response and neuroprotection.
The protection of genomic integrity is a major challenge for living cells that are continuously exposed to endogenous and environmental DNA-damaging insults. To cope with the consequences of DNA lesions which interfere with essential DNA-dependent processes including transcription and replication, cells are equipped with an efficient defense mechanism termed the DNA damage response. Its functio...
متن کاملAutophagy in DNA Damage Response
DNA damage response (DDR) involves DNA repair, cell cycle regulation and apoptosis, but autophagy is also suggested to play a role in DDR. Autophagy can be activated in response to DNA-damaging agents, but the exact mechanism underlying this activation is not fully understood, although it is suggested that it involves the inhibition of mammalian target of rapamycin complex 1 (mTORC1). mTORC1 re...
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ژورنال
عنوان ژورنال: Genome Biology
سال: 2008
ISSN: 1465-6906
DOI: 10.1186/gb-2008-9-7-227